DK Metcalf (441-5) and Tyler Lockett (441-3) form one of the league's best receiving duos, and tight ends Gerald Everett and Will Dissly have 10 catches apiece. He has excellent weapons outside, and the Saints rank 23rd against the pass, allowing 275 yards per game. Smith has shown he can keep teams in games and is 5-1 against the spread in his career in primetime despite going 1-5 straight-up. They have nine interceptions this season, and Cameron Jordan will harass Smith, who was sacked five times in his first start last week. The Saints are giving up just 18 points (fourth in NFL) and 79 rushing yards (second) per game. Wide receiver Marquez Callaway is averaging 17 yards per catch, and the team will get Tre'Quan Smith back from a hamstring injury. The Saints are 11-4-1 against the spread. Quarterback Jameis Winston (892 yards, 12 TDs) also could take his shots against the 28th-ranked pass defense. Kamara has 482 yards and four scores this season. The Seahawks rank last in the league in total yards (433 per game) and are yielding almost 141 on the ground (30th). Running back Alvin Kamara had 161 total yards and two TDs in the 2019 meeting and should be fired up to face this defense. It is well-rested and is 10-4 against the spread in its past 14 coming off a bye. New Orleans has won the two most recent matchups, pulling off upsets in 20. The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. The model also enters Week 7 of the 2021 season on an incredible 125-85 run on top-rated NFL picks that dates back to the 2017 season. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model, which simulates every NFL game 10,000 times, is up almost $7,700 for $100 players on top-rated NFL picks since its inception six-plus years ago. Saints picks, you need to check out the NFL predictions and analysis from the red-hot SportsLine Projection Model. Seahawks odds from Caesars Sportsbook, and the Over-Under for total points scored is 41.5. New Orleans is a 5.5-point favorite in the latest Saints vs. The Seahawks (2-4) lost star quarterback Russell Wilson to a finger injury that required surgery and will once again rely on the arm of Geno Smith. 10 and took over second place in the NFC South when the Panthers lost to Minnesota in Week 6. New Orleans (3-2) has had more than two weeks to recover and had won two of three before their bye. The New Orleans Saints will try to take advantage of the Seattle Seahawks' misfortune on Monday Night Football.
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